Maastricht University                                                                                                                              University Hospital of Maastricht Tumor Angiogenesis Lab angiogenese laboratory laboratorium cancer kanker onderzoek research basaal basal fundamental fundamentaal rijksuniversiteit limburg universiteit maastricht state university university maastricht hospital netherlands nederland europe europa peptiden peptide peptides endotheel endothelium endothelial vitro vivo huvec mvec arjan griffioen daisy van der schaft elly toebes puck muller susan joosten niki pappas annemarie barendsz-janson hillen wagstaff oncologie oncology hematology haematology immunology immunology wilhelmina kankerfonds foundation nederlands tijdschrift geneeskunde faculteit der gezondheidswetenschappen faculty health sciences geneeskunde medicine biology oncologielab monoclonale antilichamen monoclonal antibodies celkweek cel kweek cell culture flask flasks rpmi 1640 bFGF VEGF endostatin endostatine angiostatin angiostatine therapie therapie cure geneesmiddel genezing ziekenhuis angiogeneseremmers inhibitoren inhibitors suppressie suppression inhibiting ICAM ICAM-1 CD44 ICAM1 PF CD34 a4b3 schouten plaatjes factor isolated limb perfusion chemotherapy chemotherapie immunotherapie immunotherapie immunomodulation adhesion attachment leukocyt rolling homing platelet factor fibrine fibrinogeen judah folkman entremed gina kolata new york times bloed blood journal science wetenschappelijk scientific wetenschap diabetes diabetisch retinopathie retinopathy psoriasis epidemiologie epidemiologie NCI national international journal cancer association nationaalinstituut institute CARIM intercellular adhesion molecule intercellular adhesion molecule inter cellular adhesie rosenberg jain boston knaw koninklijke academie der wetenschappen nwo CDC harvard cambridge europese pinedo Department of Internal Medicine - University Hospital of Maastricht - The Netherlands NKI chirurgie microcirculatie onderzoek vademecum LUMC RUG leiden maastricht amsterdam VU UVA AZU Utrecht Nijmegen borstkanker mammacarcinoom mammacarcinoma breast cancer rectal rectum prostaat prostate metastasis uitzaaiingen distant spreading spread vitronectin VCAM willebrand thrombospondin american united states america oxford bill clinton cancer act vrij nederland psa

Tumor Angiogenesis Lab angiogenese laboratory Drugs that prevent new blood vessels from invading surrounding tissue: Marimastat British Biotech Annapolis, Md. Phase III Synthetic inhibitor of matrixmetalloproteinases (MMPs) Bay 12-9566 Bayer West Haven, Conn. Phase III Synthetic MMP inhibitor AG3340 Agouron LaJolla, Calif. CGS27023A Novartis East Hanover, N.J. fase 1 fase I Phase I COL-3 Collagenex Pharmaceuticals Newtown, Pa. Phase I Antibiotic derivative that inhibits MMPs Vitaxin Ixsys, Inc. LaJolla, Calif. Antibody to integrin, present on endothelial cell surface Natural inhibitors of angiogenesis: Platelet factor-4 Repligen Cambridge, Mass. Phase II Inhibits endothelial cell growth Interleukin-12 Genetics Institute Cambridge, Mass. Phase Inhibits endothelial Formation of new blood vessels is a prerequisite for outgrowth of solid tumours and metastasis. Leukaemia and lymphoma are also dependent on angiogenesis. Inhibition of angiogenesis is therefore a promising therapy for all cancer types. Angiogenic factors reduce the expression of tumour endothelial adhesion molecules for leukocytes, which enables tumours to escape the inflammation response. Antiangiogenic factors induce not only starvation of the tumour owing to deprivation of vasculature, but also re-expression of adhesion molecules, resulting in increased leukocyte infiltration. On the basis of de novo design of chemokines with antiangiogenic properties, novel inhibitors of angiogenesis are developed and selected for their ability to induce a tumour inflammatory reaction cell growth Drugs that block factors that stimulate the formation of blood vessels: tumor tumour gezwel gezwellen krebs karkino carcino RhuMabVEGF Genentech South San Francisco, Calif. Phase II/III Monoclonal antibody to vascular endothelial growth factor (VEGF) SU5416 Sugen, Inc. Redwood City, Calif. VEGF receptor signaling Interferon-alpha Inhibits release of endothelial growth factor Targeted anti-vascular therapy: ZD0101 Zeneca Pharmaceuticals Wilmington, Del. Bacterial toxin that binds to new blood vessels and induces inflammatory response Interrupts function of dividing endothelial cells: TNP-40 TAP Pharmaceuticals, Inc. Deerfield, Ill. Phase II Synthetic analogue of fungal protein;inhibits endothelial cell growth Unknown mechanism; inhibits angiogenesis in laboratory and animal assays: Thalidomide Entremed, Inc. Rockville, Md. Phase II Synthetic sedative: Unknown mechanism CAI National Cancer Institute Bethesda, Md. Phase Non-specific inhibitor cell invasion and motility Squalamine Magainin Pharmaceuticals, Inc. Plymouth Meeting, Pa. Extract from dogfish shark liver; inhibits sodium-hydrogen exchanger, NHE3 Suramin Parke-Davis Morris Plains, N.J. Non-specific multi-site effects IM862 Cytran Kirkland, Wash.
laboratorium cancer kanker onderzoek research basaal
basal fundamental fundamentaal rijksuniversiteit
limburg universiteit maastricht state university
university maastricht hospital netherlands nederland
europe europa peptiden peptide peptides endotheel
endothelium endothelial vitro vivo huvec mvec arjan
griffioen daisy van der schaft elly toebes puck muller
susan joosten niki pappas annemarie barendsz-janson
hillen wagstaff oncologie oncology hematology
haematology immunology immunologie wilhelmina
kankerfonds foundation nederlands tijdschrift
geneeskunde faculteit der gezondheidswetenschappen
faculty health sciences geneeskunde medicine biology
oncologielab monoclonale antilichamen monoclonal
antibodies celkweek cel kweek cell culture flask flasks
rpmi 1640 bFGF VEGF endostatin endostatine
angiostatin angiostatine therapie therapie cure
geneesmiddel genezing ziekenhuis angiogeneseremmers
inhibitoren inhibitors suppressie suppression inhibiting
ICAM ICAM-1 CD44 ICAM1 PF plaatjes factor
platelet factor fibrine fibrinogeen judah folkman
entremed gina kolata new york times bloed blood
journal science wetenschappelijk scientific wetenschap
epidemiologie epidemiologie NCI national nationaal
instituut institute CARIM intercellular adhesion
molecule intercellular adhesion molecule inter cellular
adhesie rosenberg jain boston knaw koninklijke
academie der wetenschappen nwo CDC harvard
cambridge europese pinedo Department of Internal
Medicine - University Hospital of Maastricht - The Netherlands